Main Encyclopedia of Signaling Molecules

Encyclopedia of Signaling Molecules

0 / 0
How much do you like this book?
What’s the quality of the file?
Download the book for quality assessment
What’s the quality of the downloaded files?

Biological processes are driven by complex systems of functionally interacting signaling molecules. Thus, understanding signaling molecules is essential to explain normal or pathological biological phenomena. A large body of clinical and experimental data has been accumulated over these years, albeit in fragmented state. Hence, systems biological approaches concomitant with the understanding of each molecule are ideal to delineate signaling networks/pathways involved in the biologically important processes. The control of these signaling pathways will enrich our healthier life.

Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.

This encyclopedia presents 350 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike

During past years, there were multiple databases to gather this information briefly and very partially. Amidst the excitement of these findings, one of the great scientific tasks of the coming century is to bring all the useful information into a place. Such an approach is arduous but at the end will infuse the lacunas and considerably be a streamline in the understanding of vibrant signaling networks. Based on this easy-approach, we can build up more complicated biological systems.

Categories:
Year:
2012
Edition:
2013
Publisher:
Springer
Language:
english
Pages:
2171 / 2077
ISBN 10:
1441904603
ISBN 13:
9781441904607
File:
PDF, 67.95 MB
Download (pdf, 67.95 MB)

Most frequently terms

 
0 comments
 

To post a review, please sign in or sign up
You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them.
1

Dermatology: Illustrated Study Guide and Comprehensive Board Review

Year:
2012
Language:
english
File:
PDF, 25.73 MB
0 / 0
2

Creative Enterprise: Contemporary Art between Museum and Marketplace

Year:
2012
Language:
english
File:
PDF, 36.65 MB
0 / 0
Encyclopedia of Signaling Molecules

Sangdun Choi
Editor

Encyclopedia of
Signaling Molecules

With 686 Figures and 86 Tables

Editor
Sangdun Choi
Department of Molecular Science and Technology
Ajou University
Suwon, Korea

ISBN 978-1-4419-0460-7
ISBN 978-1-4419-0461-4 (eBook)
DOI 10.1007/978-1-4419-0461-4
ISBN 978-1-4419-0462-1 (print and electronic bundle)
Springer New York Heidelberg Dordrecht London
Library of Congress Control Number: 2012942647
# Springer ScienceþBusiness Media, LLC 2012
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the
material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,
broadcasting, reproduction on microfilms or in any other physical way, and transmission or information
storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology
now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection
with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and
executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this
publication or parts thereof is permitted only under the provisions of the Copyright Law of the
Publisher’s location, in its current version, and permission for use must always be obtained from
Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center.
Violations are liable to prosecution under the respective Copyright Law.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication
does not imply, even in the absence of a specific statement, that such names are exempt from the relevant
protective laws and regulations and therefore free for general use.
While the advice and information in this book are believed to be true and accurate at the date of publication,
neither the authors nor the editors nor th; e publisher can accept any legal responsibility for any errors or
omissions that may be made. The publisher makes no warranty, express or implied, with respect to the
material contained herein.
Printed on acid-free paper
Springer is part of Springer ScienceþBusiness Media (www.springer.com)

Preface

Biological processes are driven by a complex system of functionally interacting
signaling components within the cell. These signaling processes are initiated when
a class of cell surface proteins, called receptors, receives information from the
surrounding environment. This information is then routed through complex signaling
pathways and decoded in the nucleus and other areas of the cell. In order to fully
understand cell signaling, we must first appreciate the spatial and temporal dynamics
of cell surface receptors as well as the downstream components of signaling
pathways. The functional states and downstream interactions of cell signaling components are critical to the understanding of both normal and pathologic biological
processes. In recent years, a steady increase in both clinical and experimental data on
cell signaling has emerged. As we progress through the twenty-first century, it is clear
that a systems biology approach, concomitant with the understanding of individual
cell signaling components, is needed to delineate biologically relevant signaling
networks. Furthermore, it is well understood that almost all diseases exhibit signaling
pathway dysfunction. As a result, there has been a profound interest in identifying
novel drug targets that regulate key signaling components in disease states.
Currently, there are more than 20,000 genes reported in the human genome;
however, not all of the encoded proteins work equally to maintain homeostasis.
Achieving a thorough understanding of the most potent signaling components and
their associated signaling pathways will significantly improve our knowledge of the
molecular mechanisms that regulate disease. Moreover, this insight will lead to
the development of novel therapeutics. In recent years, there were multiple attempts
to build molecule databases, which were still very partial and brief. Amid the
excitement over the recent discoveries of new functional molecules, one of this
century’s greatest scientific tasks is to compile all information pertaining to signaling
components into a single resource. Such an attempt may be arduous but, at the end,
will fill the intellectual voids of the field and drastically streamline the understanding
of critical signaling networks.
The Encyclopedia of Signaling Molecules is a testament to how far we have come
in terms of identifying the function of and the interconnection between signaling
molecules. This book represents biologically important signaling components from
the level of a single gene, to that of gene families. The contents of this encyclopedia
are built on the core concepts of the function of signaling components along with the
early historical findings to show readers the progress the field has achieved. The
encyclopedia not only focuses on individual and groups of signaling components, but
also explores the interactions between these groups of signaling components within
signal transduction networks. Additionally, it also provides an abundance of

v

vi

Preface

information on the conversion of external signals generated by growth factors,
hormones, neurotransmitters, chemokines, cytokines, etc., to the resultant cellular
response. Applications of these data to disease and drug discovery efforts have also
been discussed. Overall, the encyclopedia is designed to aid those who wish to
investigate the function of specific signaling molecules and its role in signaling
networks.
The encyclopedia is a Springer Major Reference Work, published in print and
online. It consists of entries organized alphabetically. Each entry is concise, clearly
written, and contains references to the literature for readers who wish to study each
topic in depth. The broad coverage is expected to make the encyclopedia an indispensable reference tool in the field of biomedical research. The online version
features colored illustrations and is fully searchable. In addition, cross-references
are listed as hyperlinks to easily access related topics in the book.
There are many people to thank and whose help was critical for completing the
Encyclopedia of Signaling Molecules. This encyclopedia is based on the expertise of
hundreds of biomedical professionals who must receive my sincere gratitude for their
dedication, efforts, and polite responsiveness to the continuous inquiries. Most
importantly, the chapter authors have written outstanding pieces that provide the
latest information in their respective field of research. I am grateful to the editors and
staffs of Springer: Ann H. Avouris, Anil Chandy, Meetu Lall, Mansi Seth, and
Rajneesh Roy for their outstanding help and assistance. Special thanks go to
Mrs. Melanie Tucker who made certain that all the molecules were included for the
final draft of the encyclopedia.
I hope that the information presented in the Encyclopedia of Signaling Molecules
will not only aid in understanding the subject matter but also in using the biological
information for the benefit of humankind.
Sangdun Choi

About the Editor

Prof. Dr. Sangdun Choi
Department of Molecular Science and
Technology
Ajou University
Suwon, 443-749
Korea
sangdunchoi@ajou.ac.kr

Sangdun Choi is currently the Chair of the Department of Biological Sciences and a
Professor at the Department of Molecular Science and Technology in Ajou University, Korea. He joined the faculty of the Department of Molecular Science and
Technology, Ajou University, as an Associate Professor in 2006. His research
interests include Toll-like receptor signaling, innate immunity, cellular signaling
and systems biology. He earned his PhD at the Texas A&M University, USA.
He was one of the pioneers in the development of Bacterial Artificial Chromosomes
(BACs). He was instrumental in the construction of a complete human BAC library
for the Human Genome Project (HGP). He was also involved in the consortium,
Alliance for Cellular Signaling (AfCS). Furthermore, he served as the Director of the
Transcription Analysis Laboratory at the California Institute of Technology
(Caltech), USA. He has published more than 200 scientific articles in international
journals including Nature, Science, Cell, Nature Biotechnology, Nature Immunology,
Immunity, Blood and Proceedings of the National Academy of Sciences. He has edited
seven books including Encyclopedia of Signaling Molecules, Systems Biology for
Signaling Networks and Introduction to Systems Biology. He is an academic editor of
PLoS ONE, an associate editor of Experimental and Molecular Medicine, and an
active editor for several other international journals. He has also served as a reviewer
for several international journals.

vii

Contributors

Brian T. Abe Department of Pathology, Albert Einstein College of Medicine,
Bronx, NY, USA
Jun-ichi Abe Aab Cardiovascular Research Institute, University of Rochester
School of Medicine and Dentistry, Rochester, NY, USA
Stephanie Affet Department of Bioscience Technologies, Program in Biotechnology, JSHP, Thomas Jefferson University, Philadelphia, PA, USA
Jacob O. Agola Department of Pathology and Cancer Center, MSC08-4640,
University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Krassimira Alexieva-Botcheva Biology Department, Brookhaven National
Laboratory, Upton, NY, USA
Irene Aligianis MRC Human Genetics Unit, Western General Hospital, Edinburgh,
Scotland, UK
Carl W. Anderson Biology Department, Brookhaven National Laboratory, Upton,
NY, USA
Douglas A. Andres Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA
Alberto Anel Departamento de Bioquı́mica, Biologı́a Molecular y Celular, Facultad
de Ciencias, Universidad de Zaragoza, Zaragoza, Spain
Adrienn Angyal Department of Cardiovascular Science, University of Sheffield,
Sheffield, South Yorkshire, UK
Alexander Annenkov Bone and Joint Research Unit, William Harvey Research
Institute, Queen Mary University of London, London, UK
Bryan A. Anthony Department of Surgery, The Ohio State University Medical
Center, Columbus, OH, USA
Ferenc András Antoni Division of Preclinical Research, EGIS Pharmaceuticals
PLC, Budapest, Hungary
Kathryn M. Appleton Department of Pharmaceutical and Biomedical Sciences,
The Medical University of South Carolina, Charleston, SC, USA
Marie Arsenian Henriksson Department of Microbiology, Tumor and Cell Biology
(MTC), Karolinska Institutet, Stockholm, Sweden
ix

x

Najla Arshad Department of Molecular Reproduction, Development and Genetics,
Indian Institute of Science, Bangalore, Karnataka, India
Shaikh M. Atif Center for Comparative Medicine, University of California Davis,
Davis, CA, USA
Manuela Baccarini Department of Microbiology and Immunobiology, Center for
Molecular Biology, University of Vienna, Max F. Perutz Laboratories, Vienna, Austria
C. T. Baldari Department of Evolutionary Biology, Universty of Siena, Siena, Italy
Ramiro Barcia Departamento de Bioquı́mica y Biologı́a Molecular, Facultad de
Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain
Betsy J. Barnes Department of Biochemistry and Molecular Biology, New Jersey
Medical School-University Hospital Cancer Center, University of Medicine and
Dentistry of New Jersey, Newark, NJ, USA
Giancarlo Barone Department of Biochemistry, University of Leicester, Leicester,
UK
Blaine Bartholomew Department of Biochemistry and Molecular Biology,
Southern Illinois University School of Medicine, Carbondale, IL, USA
Anna Baruzzi Department of Pathology and Diagnostics, Section of General
Pathology, University of Verona, Verona, Italy
Shaherin Basith Department of Molecular Science and Technology, Ajou University, Suwon, South Korea
Nirmalya Basu Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, Karnataka, India
Soumik BasuRay Department of Pathology and Cancer Center, MSC08-4640,
University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Timothy J. Bauler Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA
Joanne Baxter Department of Biochemistry, University of Leicester, Leicester, UK
Carine Becamel Dépt. de Neurobiologie, Institut de Génomique Fonctionnelle,
Unité Mixte de Recherche 5203, Centre National de la Recherche Scientifique,
Institut National de Santé et de la Recherche Médicale U661, Universités Montpellier
1 and 2, Montpellier Cedex 5, France
Elisa A. Bellomo Section of Cell Biology, Division of Diabetes, Endocrinology and
Metabolism, Faculty of Medicine, Imperial College London, South Kensington,
London, UK
Arnauld Belmer Université Pierre et Marie Curie, Institut du Fer à Moulin, Paris,
France
Armand Bensussan INSERM U976, Saint Louis Hospital, Paris cedex 10, France
Ora Bernard Cytoskeleton and Cancer Unit, St Vincent’s Institute of Medical
Research, Fitzroy, VIC, Australia

Contributors

Contributors

xi

Giorgio Berton Department of Pathology and Diagnostics, Section of General
Pathology, University of Verona, Verona, Italy
Anton Bespalov Neuroscience Research, GPRD, Abbott, Ludwigshafen,
Germany
Daniel D. Billadeau Department of Immunology, College of Medicine, Mayo
Clinic, Rochester, MN, USA
Division of Oncology Research, Schulze Center for Novel Therapeutics, College of
Medicine, Mayo Clinic, Rochester, MN, USA
Robert J. Binder Department of Immunology, University of Pittsburgh, Pittsburgh,
PA, USA
Gail A. Bishop Department of Microbiology & Internal Medicine, The University
of Iowa and VA Medical Center, Iowa City, IA, USA
Arunima Biswas Department of Developmental and Molecular Biology, Albert
Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
Esther E. Biswas-Fiss Department of Bioscience Technologies, Program in
Biotechnology, JSHP, Thomas Jefferson University, Philadelphia, PA, USA
Department of Molecular Biology, University of Medicine and Dentistry of
New Jersey, SOM, Stratford, NJ, USA
Haruhiko Bito Department of Neurochemistry, The University of Tokyo Graduate
School of Medicine, Bunkyo-ku, Tokyo, Japan
CREST–Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
Sandra Blanco Instituto de Biologı́a Molecular y Celular del Cáncer, Centro de
Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas (CSIC)Universidad de Salamanca, Salamanca, Spain
Giovanni Blandino Translational Oncogenomics Unit, Regina Elena Cancer
Institute, Rome, Italy
Francesco Blasi IFOM (Fondazione Istituto FIRC di Oncologia Molecolare),
Milan, Italy
Joelle Blot Department of Biochemistry, University of Leicester, Leicester, UK
Richard Blouin Département de Biologie, Université de Sherbrooke, Sherbrooke,
Québec, Canada
Mitsi A. Blount Renal Division, Emory University Woodruff Memorial Research
Building, Atlanta, GA, USA
Joe B. Blumer Department of Cell and Molecular Pharmacology and Experimental
Therapeutics, Medical University of South Carolina, Charleston, SC, USA
Department of Neurosciences, Medical University of South Carolina, Charleston, SC,
USA
Matthew D. Blunt Department of Pharmacy & Pharmacology, University of Bath,
Bath, Somerset, UK

xii

Joël Bockaert Dépt. de Neurobiologie, Institut de Génomique Fonctionnelle, Unité
Mixte de Recherche 5203, Centre National de la Recherche Scientifique, Institut
National de Santé et de la Recherche Médicale U661, Universités Montpellier 1 and
2, Montpellier Cedex 5, France
Jean Marie Boeynaems Department of Laboratory Medicine, Erasme Academic
Hospital, Université Libre de Bruxelles, Brussels, Belgium
Subbarao Bondada Department of Microbiology, Immunology and Molecular
Genetics, Markey Cancer Center, University of Kentucky, Lexington, KY, USA
Kaya Bork Institute for Physiological Chemistry, Martin-Luther-University
Halle-Wittenberg, Halle(Saale), Germany
Dave Boucher Department of pharmacology, Université de Sherbrooke, Sherbrooke,
QC, Canada
Robert R. Bowers Department of Cell and Molecular Pharmacology and
Experimental Therapeutics, Medical University of South Carolina, Charleston,
SC, USA
Charles D. Boyd John A. Burns School of Medicine, University of Hawaii,
Honolulu, HI, USA
Jennifer Boylston Department of Biochemistry and Program in Molecular &
Cellular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA,
USA
Maria Elena Bravo-Adame Instituto de Biotecnologı́a, Universidad Nacional
Autónoma de México, Cuernavaca, Morelos, Mexico
Catherine Brenner INSERM UMR-S 769, Université Paris-Sud XI, ChâtenayMalabry, France
Charles Brenner Department of Biochemistry and Program in Molecular &
Cellular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA,
USA
Gary Brewer Department of Molecular Genetics, Microbiology and Immunology,
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical
School, Piscataway, NJ, USA
James P. Brody Department of Biomedical Engineering, University of California,
Irvine, CA, USA
Gordon D. Brown Section of Immunology and Infection, Division of
Applied Medicine, Institute of Medical Sciences, Aberdeen Fungal Group, Aberdeen,
UK
Joshua D. Brown-Clay Department of Biochemistry and Molecular and Cellular
Biology, Georgetown University, Washington, DC, USA
Laurence L. Brunton Pharmacology, University of California San Diego, San
Diego, CA, USA

Contributors

Contributors

xiii

Brad Allen Bryan Department of Biology, Ghosh Science and Technology Center,
Worcester State University, Worcester, MA, USA
Center of Excellence in Cancer Research, Department of Biomedical Sciences, Texas
Tech University Health Sciences Center, El Paso, TX, USA
Thomas P. Burris Department of Molecular Therapeutics, The Scripps Research
Institute, Jupiter, FL, USA
Stephanie L. Burroughs Department of Ophthalmology, University of Missouri Kansas City School of Medicine, Vision Research Center, Kansas City, MO, USA
Scott A. Busby Department of Molecular Therapeutics, The Scripps Research
Institute, Jupiter, FL, USA
Xosé R. Bustelo Centro de Investigación del Cáncer/Cancer Research Center,
CSIC-University of Salamanca, Salamanca, Spain
Aisha Qasim Butt Department of Biology, Institute of Immunology, National
University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland
Bettina B€
uttner Institute for Physiological Chemistry, Martin-Luther-University
Halle-Wittenberg, Halle(Saale), Germany
Jennifer Anne Byrne Children’s Cancer Research Unit, Kids Research Institute,
The Children’s Hospital at Westmead, Westmead, NSW, Australia
Tatiana V. Byzova Department of Molecular Cardiology, Joseph J. Jacobs Center
for Thrombosis and Vascular Biology, Lerner Research Institute, The Cleveland
Clinic, Cleveland, OH, USA
Weikang Cai Department of Molecular and Cellular Biochemistry, University of
Kentucky College of Medicine, Lexington, KY, USA
Mario R. Calderon Department of Physiology, McGill University McIntyre
Medical Sciences Building, Montréal, Québec, Canada
Chunhua Cao Department of Medicine, Division of Nephrology, University of
Maryland, Baltimore, Baltimore, MD, USA
Astrid E. Cardona Department of Biology and South Texas Center for Emerging
Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, USA
Graeme K. Carnegie Department of Pharmacology, University of Illinois at
Chicago, Chicago, IL, USA
Lai N. Chan Molecular Biology Institute, Los Angeles, CA, USA
Department of Microbiology, Immunology & Molecular Genetics, University of
California, Los Angeles, CA, USA
Rakesh Chandarana Bombay College of Pharmacy, Mumbai, India
Nilanjana Chatterjee Department of Biochemistry and Molecular Biology,
Southern Illinois University School of Medicine, Carbondale, IL, USA
Jian Chen Department of Biochemistry & Molecular Biology, Michigan State
University, East Lansing, MI, USA

xiv

Xingwang Chen Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA
Yuyan Chen Children’s Cancer Research Unit, Kids Research Institute, The
Children’s Hospital at Westmead, Westmead, NSW, Australia
Frank S. Chen Department of Biochemistry and Molecular Biology, School of
Medicine, Virginia Commonwealth University, Richmond, VA, USA
Ching-Kang (Jason) Chen Department of Biochemistry and Molecular Biology,
School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
Heung-Chin Cheng Department of Biochemistry and Molecular Biology, University of Melbourne Bio21 Molecular Science and Biotechnology Institute, Parkville,
VIC, Australia
Chin Chiang Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA
Pallavi Chittoor Department of Biochemistry, Sri Venkateswara University
College of Sciences, Tirupati, AP, India
Sangdun Choi Department of Molecular Science and Technology, Ajou University,
Suwon, South Korea
Yuh-Ping Chong Edinburgh Cancer Research Centre, Western General Hospital,
Edinburgh, UK
Avik Choudhuri Department of Developmental and Molecular Biology, Albert
Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
Laurie T. C. Chow Clinical Pharmacology Unit, Department of Medicine Austin
Health/Northern Health, University of Melbourne, Heidelberg, VIC, Australia
Matthew L. H. Chu Department of Structural Biology, Stanford University School
of Medicine, Stanford, CA, USA
Jonathan H. Clarke Department of Pharmacology, University of Cambridge,
Cambridge, UK
Jaime O. Claudio Toronto General Research Institute, University Health Network,
Toronto Medical Discovery Tower, Toronto, ON, Canada
John Colicelli Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Lynne M. Coluccio Boston Biomedical Research Institute, Watertown, MA, USA
Didier Communi Institute of Interdisciplinary Research, School of Medicine,
Université Libre de Bruxelles, Brussels
Christopher T. Cottage San Diego State Heart Institute, San Diego State University, San Diego, CA, USA
Evans C. Coutinho Bombay College of Pharmacy, Mumbai, India
Jean-Philippe Couture Département de Biologie, Université de Sherbrooke,
Sherbrooke, Québec, Canada

Contributors

Contributors

xv

Dianne Cox Department of Anatomy and Structural Biology, Albert Einstein
College of Medicine, Jack and Pearl Resnick Campus, Bronx, NY, USA
Carl E. Creutz Department of Pharmacology, University of Virginia, Virginia,
VA, USA
Katalin Csiszar John A. Burns School of Medicine, University of Hawaii,
Honolulu, HI, USA
Fernando Queiroz Cunha Inflammation lab, Department of Pharmacology, School
of Medicine of Ribeirão Preto, São Paulo University – FMRP/USP, Ribeirao Preto,
SP, Brazil
Ian Cushman Department of Pharmacology and Cancer Biology, Duke University
Medical Center, Durham, NC, USA
Karin Dahlman-Wright Department of Biosciences and Nutrition, Novum,
Karolinska Institutet, Huddinge, Sweden
Alexander H. Dalpke Department of Infectious Diseases, Medical Microbiology
and Hygiene, University of Heidelberg, Heidelberg, Germany
Ben Davies Wellcome Trust Centre for Human Genetics, University of Oxford
Roosevelt Drive, Oxford, UK
Dima A. Decker Department of Microbiology & Internal Medicine, The University
of Iowa and VA Medical Center, Iowa City, IA, USA
Francesca Deflorian Laboratory of Bioorganic Chemistry & Molecular Recognition Section, National Institute of Diabetes & Digestive & Kidney Diseases, National
Institutes of Health, Bethesda, MD, USA
James H. DeFord Department of Biochemistry and Molecular Biology, University
of Texas Medical Branch, Galveston, TX, USA
Jennifer Defren Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson
Medical School, Piscataway, NJ, USA
Austin Della-Franca Children’s Cancer Research Unit, Kids Research Institute,
The Children’s Hospital at Westmead, Westmead, NSW, Australia
Brian R. Dempsey Department of Biochemistry, The University of Western
Ontario, London, ON, Canada
Jean-Bernard Denault Department of pharmacology, Université de Sherbrooke,
Sherbrooke, QC, Canada
Carmen W. Dessauer Department of Integrative Biology and Pharmacology,
University of Texas Health Science Center at Houston, Houston, TX, USA
Sumit Deswal Max Planck Institute of Immunobiology and Faculty of Biology,
Biology III, University of Freiburg, Freiburg, Germany
Spemann Graduate School of Biology and Medicine, Freiburg, Germany
Sandeepa Dey Department of Cell Biology, The Scripps Research Institute,
La Jolla, CA, USA

xvi

Silvina Laura Diaz Université Pierre et Marie Curie, Institut du Fer à Moulin, Paris,
France
Jonathan R. Dimmock Drug Design and Discovery Research Group, College of
Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada
Shabana Din San Diego State Heart Institute, San Diego State University,
San Diego, CA, USA
Rachel Doidge School of Pharmacy, Centre for Biomolecular Sciences, University
of Nottingham, Nottingham, UK
Stéphane Doly Université Pierre et Marie Curie, Institut du Fer à Moulin, Paris,
France
Johnna Dominick Department of Molecular and Cellular Biochemistry, Center for
Molecular Neurobiology, Ohio State Biochemistry Program Ohio State University,
Columbus, OH, USA
Molecular & Cellular Biochemistry, Ohio State University, Columbus, OH, USA
Dominique M. Donato Physics of Life Processes, Leiden Institute of Physics,
Leiden University, CA, Leiden, The Netherlands
H. Henry Dong Division of Immunogenetics, Department of Pediatrics, Rangos
Research Center, Children’s Hospital of Pittsburgh of UPMC, University of
Pittsburgh School of Medicine, Pittsburgh, PA, USA
Athanassios Dovas Department of Anatomy and Structural Biology, Albert Einstein
College of Medicine, Jack and Pearl Resnick Campus, Bronx, NY, USA
Gerard Drewes Discovery Research, Cellzome AG, Heidelberg, Germany
Kirk M. Druey Laboratory of Allergic Diseases, National Institute of Allergy and
infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Jacinta S. D’Souza UM-DAE-Centre for Excellence in Basic Sciences, Kalina
campus, Santacruz (E), Mumbai, India
Xiaoyu Du The Rosalind & Morris Goodman Cancer Research Center, McGill
University, Québec, Canada
Department of Medicine, McGill University Health Center, Montréal, Québec, Canada
Vikas V. Dukhande Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA
Denis J. Dupré Department of Pharmacology, Dalhousie University, Nova Scotia,
Canada
Norman L. Eberhardt Departments of Medicine and Biochemistry & Molecular
Biology, Mayo Clinic, Rochester, MN, USA
Sean E. Egan Program in Developmental & Stem Cell Biology, The Hospital for
Sick Children, Toronto, ON, Canada

Contributors

Contributors

xvii

Aristides G. Eliopoulos Molecular & Cellular Biology Laboratory, Division of
Basic Sciences, University of Crete Medical School, Heraklion, Crete, Greece
Institute for Molecular Biology & Biotechnology, Foundation of Research & Technology Hellas (FORTH), Heraklion, Crete, Greece
Ari Elson Department of Molecular Genetics, Arnold R. Meyer Institute of Biological Sciences, The Weizmann Institute of Science, Rehovot, Israel
Marina Rode von Essen Department of International Health, Immunology and
Microbiology, University of Copenhagen, Copenhagen, DK, Denmark
Patrick A. Eyers YCR Institute for Cancer Studies, University of Sheffield,
Sheffield, UK
Zakaria Ezzoukhry Laboratoire de Biochimie, Inserm ERI12 – EA4292,
Université de Picardie Jules Verne (UPJV), Amiens Cedex, France
Bj€
orn H. Falkenburger Department of Neurology, RWTH University Medical
Center, Aachen, Germany
Angharad E. Fenton-May Centre for Cellular and Molecular Physiology,
Nuffield Department of Clinical Medicine, University of Oxford, Headington,
Oxford, UK
Isabel F. Fernández Instituto de Biologı́a Molecular y Celular del Cáncer, Centro
de Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas (CSIC)Universidad de Salamanca, Salamanca, Spain
Alberto Fernández-Medarde Centro de Investigación del Cáncer, IBMCC (CSIC/
USAL), University of Salamanca, Salamanca, Spain
M. Ferro Department of Evolutionary Biology, Universty of Siena, Siena, Italy
Katherine Figella Department of Biology, Ghosh Science and Technology Center,
Worcester State University, Worcester, MA, USA
Kathryn Finton Division of Basic Sciences, Fred Hutchinson Cancer Research
Center, Seattle, WA, USA
Giulia Fontemaggi Translational Oncogenomics Unit, Regina Elena Cancer Institute, Rome, Italy
Sonia-Vanina Forcales Institute of Predictive and Personalized Medicine of Cancer
(IMPPC), Badalona, Barcelona, Spain
Albert J. Fornace Jr. Department of Biochemistry and Molecular and Cellular
Biology, Georgetown University, Washington, DC, USA
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC,
USA
Anna Frenzel Department of Microbiology, Tumor and Cell Biology (MTC),
Karolinska Institutet, Stockholm, Sweden
Jeffrey A. Frost Department of Integrative Biology and Pharmacology, University
of Texas Health Science Center at Houston, Houston, TX, USA

xviii

David A. Fruman Department of Molecular Biology & Biochemistry, University of
California, Irvine, CA, USA
Andrew Fry Department of Biochemistry, University of Leicester, Leicester,
UK
Masakazu Fujiwara Department of Molecular Pathology, Institute of Development
and Aging Sciences, Graduate School of Medicine, Nippon Medical School,
Kawasaki, Kanagawa, Japan
Masaki Fukata Division of Membrane Physiology, Department of Cell Physiology,
National Institute for Physiological Sciences, Okazaki, Aichi, Japan
Department of Physiological Sciences, School of Life Science, The Graduate
University for Advanced Studies (SOKENDAI), Aichi, Japan
Yuko Fukata Division of Membrane Physiology, Department of Cell Physiology,
National Institute for Physiological Sciences, Okazaki, Aichi, Japan
Department of Physiological Sciences, School of Life Science, The Graduate
University for Advanced Studies (SOKENDAI), Aichi, Japan
Mitsunori Fukuda Laboratory of Membrane Trafficking Mechanisms, Department
of Developmental Biology and Neurosciences, Graduate School of Life Sciences,
Tohoku University, Sendai, Miyagi, Japan
Matthias Gaestel Hannover Medical School, Institute of Biochemistry, Hannover,
Germany
Thierry Galli Membrane Traffic in Neuronal & Epithelial Morphogenesis,
INSERM ERL U950, Paris, France
Program in Development & Neurobiology, Jacques Monod Institute, CNRS
UMR7592, Paris, France
University Denis Diderot–Paris 7, Paris, France
Kathleen A. Gallo Department of Physiology, Michigan State University, East
Lansing, MI, USA
Cell & Molecular Biology Program, Michigan State University, East Lansing, MI,
USA
Lorenzo Galluzzi INSERM, U848, Institut Gustave Roussy, Université Paris-Sud
XI, Villejuif, France
Antoine Galmiche Laboratoire de Biochimie, Inserm ERI12 – EA4292, Université
de Picardie Jules Verne (UPJV), Amiens Cedex, France
Zhan-Guo Gao Laboratory of Bioorganic Chemistry & Molecular Recognition
Section, National Institute of Diabetes & Digestive & Kidney Diseases, National
Institutes of Health, Bethesda, MD, USA
Gustavo Pompermaier Garlet OSTEOimmunology lab, Department of Biological
Sciences, School of Dentistry of Bauru, São Paulo University – FOB/USP, Bauru,
SP, Brazil

Contributors

Contributors

xix

Thiago Pompermaier Garlet Inflammation lab, Department of Pharmacology,
School of Medicine of Ribeirão Preto, São Paulo University – FMRP/USP, Ribeirao
Preto, SP, Brazil
Joanna E. Gawecka University of Hawai’i Cancer Center, University of Hawai’i at
Manoa, Honolulu, HI, USA
Carsten Geisler Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, DK, Denmark
Matthew S. Gentry Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA
Mesfin Gewe Division of Basic Sciences, Fred Hutchinson Cancer Research Center,
Seattle, WA, USA
Andreas Gewies Laboratory for Signaling in the Immune System, Helmholtz
Zentrum M€
unchen – German Research Center for Environmental Health,
Neuherberg, Germany
Mohammad Ghazizadeh Department of Molecular Pathology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School,
Kawasaki, Kanagawa, Japan
N. Giommoni Department of Evolutionary Biology, Universty of Siena, Siena, Italy
Daryl L. Goad Department of Ophthalmology and Department of Basic Medical
Science, University of Missouri - Kansas City School of Medicine, Vision Research
Center, Kansas City, MO, USA
Catherine Godson UCD Diabetes Research Centre, UCD Conway Institute, School
of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
Susan Goebel-Goody Child Study Center, School of Medicine, Yale University,
New Haven, CT, USA
Julian Gomez-Cambronero Department of Biochemistry and Molecular Biology,
Wright State University School of Medicine, Dayton, OH, USA
João Gonçalves Centro de Quı́mica e Bioquı́mica, Lisbon, Portugal
Instituto Gulbenkian de Ciência, Oeiras, Portugal
Jose-Luis González de Aguilar Laboratory of Molecular Signaling and
Neurodegeneration, INSERM, Faculty of Life Sciences, University of Strasbourg,
Strasbourg, France
Luisa Gorza Department of Biomedical Sciences, University of Padova, Padova,
Italy
Benjamin J. Gosney Institute of Life Science, School of Medicine, Swansea
University, Swansea, Wales, UK
Noriko Gotoh Institute of Medical Science, The University of Tokyo, Minato-ku,
Tokyo, Japan
Michael T. Greenwood Department of Chemistry and Chemical Engineering,
Royal Military College of Canada, Kingston, ON, Canada

xx

Michael A. Grillo Department of Ophthalmology and Department of Basic Medical
Science, University of Missouri - Kansas City School of Medicine, Vision Research
Center, Kansas City, MO, USA
Julian Hendrik Gronau Division of Cancer, Department of Surgery & Cancer,
Imperial College London, Hammersmith Hospital, London, UK
Haihua Gu Department of Pathology, University of Colorado Denver, Aurora,
CO, USA
Marga Gual-Soler Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
Donald Gullberg Department of Biomedicine, University of Bergen, Bergen,
Norway
Mads Gyrd-Hansen Novo Nordisk Foundation Center for Protein Research,
University of Copenhagen, Copenhagen, Denmark
Malissa Ha Department of Bioscience Technologies, Program in Biotechnology,
JSHP, Thomas Jefferson University, Philadelphia, PA, USA
Gregg A. Hadley Department of Surgery, The Ohio State University Medical
Center, Columbus, OH, USA
Tsonwin Hai Department of Molecular and Cellular Biochemistry, Center for
Molecular Neurobiology, Ohio State Biochemistry Program Ohio State University,
Columbus, OH, USA
Molecular & Cellular Biochemistry, Ohio State University, Columbus, OH, USA
Michelle L. Halls Department of Pharmacology, University of Cambridge,
Cambridge, UK
Mark Handley MRC Human Genetics Unit, Western General Hospital, Edinburgh,
Scotland, UK
Dorit Hanein Bioinformatics and Systems Biology Program, Sanford-Burnham
Medical Research Institute, La Jolla, CA, USA
Steven K. Hanks Department of Cell and Developmental Biology, Vanderbilt
University School of Medicine, Nashville, TN, USA
Hiromitsu Hara Division of Molecular and Cellular Immunoscience, Department
of Biomolecular Sciences, Saga University, Saga, Japan
Kenneth W. Harder Department of Microbiology and Immunology, Life Sciences
Institute, University of British Columbia, Vancouver, BC, Canada
Nirmala Hariharan San Diego State Heart Institute, San Diego State University,
San Diego, CA, USA
Christian Harteneck Department of Pharmacology and Experimental Therapy,
Institute of Experimental and Clinical Pharmacology and Toxicology, Interfaculty
Center of Pharmacogenomics and Pharmaceutical Research (ICePhA), EberhardKarls-University, T€
ubingen, Germany

Contributors

Contributors

xxi

Amanda Harvey Brunel Institute for Cancer Genetics and Pharmacogenomics,
Brunel University, West London, UK
Debbie L. Hay School of Biological Sciences, University of Auckland, Auckland,
New Zealand
Terence E. Hébert Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada
Jyrki Heino Department of Biochemistry and Food Chemistry, University of Turku,
Turku, Finland
Karen M. Henkels Department of Biochemistry and Molecular Biology, Wright
State University School of Medicine, Dayton, OH, USA
Jonathan J. Henry Department of Cell and Developmental Biology, University of
Illinois at Urbana-Champaign, Urbana, IL, USA
Jeniffer B. Hernandez Institute for Immunology and Department of Molecular
Biology & Biochemistry, University of California, Irvine, CA, USA
Deike Hesse Department of Experimental Diabetology, German Institute of Human
Nutrition Potsdam-Rehbr€ucke, Nuthetal, Germany
Randa Hilal-Dandan Pharmacology, University of California San Diego,
San Diego, CA, USA
Ping-Chih Ho Department of Pharmacology, University of Minnesota Medical
School, Minneapolis, MN, USA
Thomas G. Hofmann Cellular Senescence (A210), German Cancer Research
Center, Heidelberg, Germany
Arie Horowitz Department of Molecular Cardiology, Lerner Research Institute,
Cleveland Clinic Foundation and Department of Physiology and Biophysics,
Case Western Reserve University, Cleveland, OH, USA
R€
udiger Horstkorte Institute for Physiological Chemistry, Martin-Luther-University
Halle-Wittenberg, Halle(Saale), Germany
Richard Horuk Department of Pharmacology, UC Davis, Davis, CA, USA
Mohammed Iqbal Hossain Department of Biochemistry and Molecular Biology,
University of Melbourne Bio21 Molecular Science and Biotechnology Institute,
Parkville, VIC, Australia
Bruce S. Hostager Department of Pediatrics, University of Iowa, Iowa City, IA,
USA
Miles D. Houslay Molecular Pharmacology Group, Institute of Neuroscience and
Psychology, CMVLS, University of Glasgow, Glasgow, Scotland, UK
Ching-Chyuan Hsieh Department of Biochemistry and Molecular Biology,
University of Texas Medical Branch, Galveston, TX, USA
Yuan-Hao Hsu Department of Chemistry, Tunghai University, Taichung, Taiwan

xxii

Dongli Hu Department of Tumor Cell Biology, St. Jude Children’s Research
Hospital, Memphis, TN, USA
Kun Huang Department of Biomedical Informatics, OSUCCC Biomedical Informatics Shared Resources, Ohio State University, Columbus, OH, USA
Masatoshi Inoue Department of Neurochemistry, The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan
Giorgio Iotti IFOM (Fondazione Istituto FIRC di Oncologia Molecolare), Milan,
Italy
Nancy Y. Ip Division of Life Science, Molecular Neuroscience Center and State
Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science
and Technology, Kowloon, Hong Kong
Robin F. Irvine Department of Pharmacology, University of Cambridge,
Cambridge, UK
Clare M. Isacke Breakthrough Breast Cancer Research Centre, The Institute of
Cancer Research, London, UK
Jeff S. Isenberg Division of Pulmonary, Allergy and Critical Care Medicine,
University of Pittsburgh School of Medicine and the Vascular Medicine Institute of
the University of Pittsburgh, Pittsburgh, PA, USA
Hiroshi Itoh Department of Medical Science, Nara Institute of Science and
Technology, Ikoma, Nara, Japan
Ryo Iwamoto Department of Cell Biology, Research Institute for Microbial
Diseases, Osaka University, Suita, Osaka, Japan
Maria C. Izquierdo IIS-Fundacion Jimenez Diaz and Universidad Autonoma de
Madrid, Madrid, Spain
Kenneth A. Jacobson Laboratory of Bioorganic Chemistry & Molecular Recognition Section, National Institute of Diabetes & Digestive & Kidney Diseases, National
Institutes of Health, Bethesda, MD, USA
David A. Jans Nuclear Signalling Laboratory, Department of Biochemistry and
Molecular Biology, Monash University, Clayton, VIC, Australia
Christine Janson Department of Biological Chemistry, David Geffen School of
Medicine at UCLA, Los Angeles, CA, USA
Alexander Jaschke Department of Experimental Diabetology, German Institute of
Human Nutrition Potsdam-Rehbr€
ucke, Nuthetal, Germany
M. P. Suresh Jayasekara Laboratory of Bioorganic Chemistry & Molecular
Recognition Section, National Institute of Diabetes & Digestive & Kidney Diseases,
National Institutes of Health, Bethesda, MD, USA
Patricia A. Jim Department of Pathology and Cancer Center, MSC08-4640,
University of New Mexico Health Sciences Center, Albuquerque, NM, USA

Contributors

Contributors

xxiii

Pauline Johnson Department of Microbiology and Immunology, Life Sciences
Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver,
BC, Canada
Faye M. Johnson Department of Thoracic/Head and Neck Medical Oncology,
Unit 432, The University of Texas MD Anderson Cancer Center, Houston, TX,
USA
The University of Texas Graduate School of Biomedical Sciences at Houston,
Houston, TX, USA
Simon Kaja Department of Ophthalmology, University of Missouri - Kansas City
School of Medicine, Vision Research Center, Kansas City, MO, USA
Wataru Kakegawa Department of Neurophysiology, School of Medicine, Keio
University, Shinjuku-ku, Tokyo, Japan
Theodosia A. Kalfa Cancer and Blood Diseases Institute, Cincinnati Children’s
Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
Mohd Aizuddin Kamaruddin Department of Biochemistry and Molecular Biology, University of Melbourne Bio21 Molecular Science and Biotechnology Institute,
Parkville, VIC, Australia
Venkateswarlu Kanamarlapudi Institute of Life Science, School of Medicine,
Swansea University, Swansea, Wales, UK
Ana Kasirer-Friede Department of Medicine, University of California, La Jolla,
San Diego, CA, USA
Masaru Katoh Division of Integrative Omics and Bioinformatics, National Cancer
Center, Tokyo, Japan
Gurpreet Kaur Nuclear Signalling Laboratory, Department of Biochemistry and
Molecular Biology, Monash University, Clayton, VIC, Australia
Thyaga Raju Kedam Department of Biochemistry, Sri Venkateswara University
College of Sciences, Tirupati, AP, India
Bethany A. Kerr Department of Molecular Cardiology, Joseph J. Jacobs Center for
Thrombosis and Vascular Biology, Lerner Research Institute, The Cleveland Clinic,
Cleveland, OH, USA
Anupriya Khare Division of Pulmonary, Allergy and Critical Care Medicine,
Department of Medicine, and Department of Immunology, University of Pittsburgh
School of Medicine, Pittsburgh, PA, USA
Sandeep Khurana Department of Medicine, Division of Gastroenterology,
University of Maryland, Baltimore, Baltimore, MD, USA
Friedemann Kiefer Department Vascular Cell Biology, Max Planck Institute for
Molecular Biomedicine, Mammalian Cell Signaling Laboratory, M€unster, Germany
Werner Kilb Institute of Physiology & Pathophysiology, University Medical
Center Mainz, Mainz, Germany

xxiv

Yong-Sung Kim Department of Molecular Science and Technology, Ajou University, Yeongtong-Gu, Suwon, South Korea
Young Woo Kim College of Pharmacy, Seoul National University, Seoul, South
Korea
Dae Hyun Kim Division of Immunogenetics, Department of Pediatrics, Rangos
Research Center, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Sang Geon Kim College of Pharmacy, Seoul National University, Seoul, South
Korea
Adam J. Kimple Department of Pharmacology, University of North Carolina at
Chapel Hill, Chapel Hill, NC, USA
Akihiro Kimura Laboratory of Immune Regulation, Osaka University Graduate
School of Frontier Biosciences, Osaka, Japan
Philip D. King Department of Microbiology and Immunology, University of
Michigan Medical School, Ann Arbor, MI, USA
Christiane Kirchhoff Department of Andrology, University Hospital HamburgEppendorf, Hamburg, Germany
Hatice Zeynep Kirli Department of Molecular Biosciences, University of Oslo,
Oslo, Norway
Tadamitsu Kishimoto Laboratory of Immune Regulation, Osaka University
Graduate School of Frontier Biosciences, Osaka, Japan
Endre Kiss-Toth Department of Cardiovascular Science, University of Sheffield,
Sheffield, South Yorkshire, UK
Janet D. Klein Renal Division, Emory University Woodruff Memorial Research
Building, Atlanta, GA, USA
Sonia Klinger Institut de Recherche en Immunologie et Cancérologie, Université de
Montréal, Montreal, QC, Canada
Masaaki Kobayashi Department of Physiology, Toho University School of Medicine, Ohta-ku, Toyko, Japan
Karl-Wilhelm Koch Department of Biology and Environmental Sciences, University of Oldenburg, Oldenburg, Germany
Kazuhisa Kohda Department of Neurophysiology, School of Medicine, Keio
University, Shinjuku-ku, Tokyo, Japan
Walter Kolch Systems Biology Ireland, University College Dublin, Dublin, Ireland
UCD Conway Institute of Biomolecular and Biomedical Research, University
College Dublin, Dublin, Ireland
Shigeru Komaba Boston Biomedical Research Institute, Watertown, MA, USA

Contributors

Contributors

xxv

Sebastian K€
onigsberger Department Vascular Cell Biology, Max Planck Institute
for Molecular Biomedicine, Mammalian Cell Signaling Laboratory, M€unster,
Germany
Diamantis Konstantinidis Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine,
Cincinnati, OH, USA
Jun Kotera Advanced Medical Research Laboratories, Mitsubishi Tanabe Pharma
Corporation, Yokohama, Kanagawa, Japan
Alexey Kotlyarov Institute of Biochemistry, Hannover Medical School, Hannover,
Germany
Peter Koulen Department of Ophthalmology and Department of Basic Medical
Science, University of Missouri - Kansas City School of Medicine, Vision Research
Center, Kansas City, MO, USA
Eva Krieghoff-Henning Cellular Senescence (A210), German Cancer Research
Center, Heidelberg, Germany
Sergei Krirschuk Institute of Physiology & Pathophysiology, University Medical
Center Mainz, Mainz, Germany
Nandini Krishnamoorthy Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, and Department of Immunology, University of
Pittsburgh School of Medicine, Pittsburgh, PA, USA
Jayalakshmi Krishnan Department of Molecular Science and Technology, Ajou
University, Suwon, South Korea
Guido Kroemer INSERM U848, Institut Gustave Roussy, Villejuif cedex, France
University Paris 11, Orsay, France
Institut Gustave Roussy, Villejuif cedex, France
Satoshi Kubota Department of Biochemistry and Molecular Dentistry, Okayama
University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
Okayama, Okayama, Japan
Sujeet Kumar Department of Pathology and Laboratory Medicine, College of
Medicine, University of Saskatchewan, Saskatoon, SK, Canada
Cancer Research Unit, Saskatchewan Cancer Agency, Saskatoon, SK, Canada
Ashok Kumar Center for Cancer Research, Children’s Hospital Oakland Research
Institute, Oakland, CA, USA
Divya Kurumala Department of Biochemistry, Sri Venkateswara University
College of Sciences, Tirupati, AP, India
Pradeep Kurup Child Study Center, School of Medicine, Yale University,
New Haven, CT, USA
Rozalia Laczko John A. Burns School of Medicine, University of Hawaii,
Honolulu, HI, USA

xxvi

Jill M. Lahti Department of Tumor Cell Biology, St. Jude Children’s Research
Hospital, Memphis, TN, USA
Kwok-On Lai Division of Life Science, Molecular Neuroscience Center and State
Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science
and Technology, Kowloon, Hong Kong
Pui Man Rosalind Lai Neuroscience Program, Wellesley College, Wellesley, MA,
USA
Harvard Medical School, Boston, MA, USA
Maréne Landstr€
om Department of Medical Biosciences, Department of Pathology,
Umeå University, Umeå, Sweden
Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden
Stephen M. Lanier Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, USA
Philip E. Lapinski Department of Microbiology and Immunology, University of
Michigan, Medical School, Ann Arbor, MI, USA
Kelvin Lau Department of Biochemistry and Molecular Biology, University of
British Columbia, Vancouver, BC, Canada
Pedro A. Lazo Instituto de Biologı́a Molecular y Celular del Cáncer, Centro de
Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas (CSIC)Universidad de Salamanca, Salamanca, Spain
Antigone Lazou School of Biology, Aristotle University of Thessaloniki,
Thessaloniki, Greece
Nhat-Tu Le Aab Cardiovascular Research Institute, University of Rochester School
of Medicine and Dentistry, Rochester, NY, USA
Woo Hyung Lee College of Pharmacy, Seoul National University, Seoul, South
Korea
Jong Ran Lee Department of Life Science, College of Natural Sciences, Ewha
Womans University, Seoul, South Korea
Yong-Hun Lee Case Comprehensive Cancer Center, Case Western Reserve
University, Cleveland, OH, USA
Philippe Lenormand Institute of Developmental Biology and Cancer, CNRS
UMR6543, Université de Nice, Nice, France
Nicholas R. Leslie Division of Cell Signalling and Immunology, College of Life
Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee, UK
Shoshana Levy School of Medicine – Division of Oncology Center for Clinical
Sciences Research, Stanford University, Stanford, CA, USA
Feng-Qian Li Department of Pharmacological Sciences, Stony Brook University,
Stony Brook, NY, USA

Contributors

Contributors

xxvii

Linfang Li Institute of Evolution & Marine Biodiversity, Ocean University of
China, Qingdao, China
Willis X. Li Department of Medicine, University of California San Diego, La Jolla,
CA, USA
Bruce T. Liang Calhoun Cardiovascular Center, University of Connecticut Health
Center, Farmington, CT, USA
Su Jun Lim University of Rochester Medical Center, Rochester, NY, USA
Fan-ching Lin Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick,
MD, USA
Rafael Linden Laboratorio de Neurogenese, Instituto de Biofisica da UFRJ,
Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
David W. Litchfield Department of Biochemistry, Schulich School of Medicine &
Dentistry, The University of Western Ontario, London, ON, Canada
Department of Oncology, Schulich School of Medicine & Dentistry, The University
of Western Ontario, London, ON, Canada
Mingyao Liu Department of Molecular and Cellular Medicine, Institute of
Biosciences and Technology, Texas A&M University Health Science Center,
Houston, TX, USA
Zhenhui Liu Department of Marine Biology, Key Laboratory of Marine Genetics
and Breeding, Ocean University of China, Qingdao, PR, China
Paul Lombroso Child Study Center, School of Medicine, Yale University,
New Haven, CT, USA
Inmaculada López-Sánchez Instituto de Biologı́a Molecular y Celular del Cáncer,
Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas
(CSIC)-Universidad de Salamanca, Salamanca, Spain
William J. Louis Clinical Pharmacology Unit, Department of Medicine Austin
Health/Northern Health, University of Melbourne, Heidelberg, VIC, Australia
Simon N. S. Louis Clinical Pharmacology Unit, Department of Medicine Austin
Health/Northern Health, University of Melbourne, Heidelberg, VIC, Australia
Thomas J. Lukas Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, IL, USA
Sarah C. R. Lummis Department of Biochemistry, University of Cambridge,
Cambridge, UK
Alex Lyakhovich Duke-National University of Singapore Graduate Medical
School, Singapore
Fernando Macian Department of Pathology, Albert Einstein College of Medicine,
Bronx, NY, USA
Jeffrey P. MacKeigan Center for Cancer Genomics and Quantitative Biology, Van
Andel Research Institute, Grand Rapids, MI, USA

xxviii

Kathrin Maedler Center for Biomolecular Interactions, University of Bremen,
Bremen, Germany
Luiz Alexandre V. Magno INCT de Medicina Molecular, Universidade Federal de
Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Umadas Maitra Department of Developmental and Molecular Biology, Albert
Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
Romit Majumdar Department of Developmental and Molecular Biology, Albert
Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
Balachandran Manavalan Department of Molecular Science and Technology,
Ajou University, Suwon, South Korea
Anne Marie-Cardine INSERM U976, Saint Louis Hospital, Paris cedex 10, France
Philippe Marin Dépt. de Neurobiologie, Institut de Génomique Fonctionnelle,
Unité Mixte de Recherche 5203, Centre National de la Recherche Scientifique,
Institut National de Santé et de la Recherche Médicale U661, Universités Montpellier
1 and 2, Montpellier Cedex 5, France
Barbara Mariniello Endocrinology Unit, Department of Medical and Surgical
Sciences, University of Padua, Padua, Italy
Thomais Markou School of Biology, Aristotle University of Thessaloniki,
Thessaloniki, Greece
Luc Maroteaux Université Pierre et Marie Curie, Institut du Fer à Moulin, Paris,
France
Kirill A. Martemyanov Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida, USA
Luis Martinez-Lostao Departamento de Bioquı́mica, Biologı́a Molecular y Celular,
Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain
Vilma R. Martins International Center for Research and Education Antonio
Prudente Foundation, A.C. Camargo Hospital, São Paulo, SP, Brazil
Hisao Masai Genome Dynamics Project, Department of Genome Medicine, Tokyo
Metropolitan Institute of Medical Science, Tokyo, Japan
Shinji Matsuda Department of Neurophysiology, School of Medicine, Keio
University, Shinjuku-ku, Tokyo, Japan
Keiko Matsuda Department of Neurophysiology, School of Medicine, Keio
University, Shinjuku-ku, Tokyo, Japan
Motozumi Matsui Department of Clinical Veterinary Science, Obihiro University
of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
Julie A. Maupin-Furlow Department of Microbiology and Cell Science, University
of Florida, Gainesville, FL, USA
Jean-Claude Maziere Laboratoire de Biochimie, Inserm ERI12 – EA4292,
Université de Picardie Jules Verne (UPJV), Amiens Cedex, France

Contributors

Contributors

xxix

Michael T. McCarthy Centre for Cellular and Molecular Physiology, Nuffield
Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK
Stephen J. McSorley Center for Comparative Medicine, University of California
Davis, Davis, CA, USA
Thomas E. Meigs Dept. of Biology, University of North Carolina Asheville,
Asheville, NC, USA
Eisuke Mekada Department of Cell Biology, Research Institute for Microbial
Diseases, Osaka University, Suita, Osaka, Japan
Sylvain Meloche Department of Pharmacology, Institut de Recherche en
Immunologie et Cancérologie, Université de Montréal, Montreal, QC, Canada
Program of Molecular Biology, Institut de Recherche en Immunologie et
Cancérologie, Université de Montréal, Montreal, QC, Canada
Triana Merced Instituto de Biologı́a Molecular y Celular del Cáncer, Centro de
Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas (CSIC)Universidad de Salamanca, Salamanca, Spain
Sinéad M. Miggin Department of Biology, Institute of Immunology, National
University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland
Oscar Arturo Migueles-Lozano Instituto de Biotecnologı́a, Universidad Nacional
Autónoma de México, Cuernavaca, Morelos, Mexico
Toru Miki Laboratory of Cellular Signaling, Nagaoka University of Technology,
Niigata, Japan
Francesca Milanesi IFOM, Milan, Italy
Laurence J. Miller Department of Molecular Pharmacology and Experimental
Therapeutics and Department of Internal Medicine, Division of Gastroenterology,
Mayo Clinic, Scottsdale, AZ, USA
Yu Ming Department of Clinical Neuroscience, Karolinska Institute, Stockholm,
Sweden
Hugo V. Miranda Department of Microbiology and Cell Science, University of
Florida, Gainesville, FL, USA
Anita R. Mistry Centre for Cellular and Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK
Maria Mittelbrunn Centro Vascular Biology and Inflamation Department, Centro
Nacional de Investigaciones Cardiovasculares, Madrid, Spain
Tooru Mizuno University of Manitoba, Winnipeg, MB, Canada
Achim M€
oller Neuroscience Research, GPRD, Abbott, Ludwigshafen, Germany
Nazanine Modjtahedi INSERM U848, Institut Gustave Roussy, Villejuif cedex,
France
University Paris 11, Orsay, France
Institut Gustave Roussy, Villejuif cedex, France

xxx

Elek Molnár MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Medical Sciences Building, University Walk,
Bristol, UK
Diana M. Monsalve Instituto de Biologı́a Molecular y Celular del Cáncer, Centro de
Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas (CSIC)Universidad de Salamanca, Salamanca, Spain
Jean Morisset Service de gastroentérologie, Département de médecine, Université
de Sherbrooke, Sherbrooke, Québec, Canada
Joel Moss Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood
Institute, National Institutes of Health, Bethesda, MD, USA
Makoto Murakami Lipid Metabolism Project, The Tokyo Metropolitan Institute of
Medical Science, Setagaya-ku, Tokyo, Japan
Natarajan Muthusamy Department of Hematology, Ohio State Comprehensive
Cancer Center, Ohio State University, Columbus, OH, USA
Maria Aparecida Nagai Disciplina de Oncologia, Departamento de Radiologia da
Faculdade de Medicina da, Centro de Investigação Translacional em Oncologia,
Laboratório de Genética Molecular, Instituto do Cancer de São Paulo, Universidade
de São Paulo, São Paulo, Brazil
Tetsuji Naka Laboratory for Immune Signal, National Institute of Biomedical
Innovation, Osaka, Japan
Hiroyuki Nakanishi Department of Molecular Pharmacology, Graduate School of
Medical Sciences, Kumamoto University, Kumamoto, Japan
Tomoki Nakashima Department of Cell Signaling, Graduate School of Medical
and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo,
Japan
Japan Science and Technology Agency (JST), Explorative Research for Advanced
Technology (ERATO) Program, Takayanagi Osteonetwork Project, Bunkyo-ku,
Tokyo, Japan
Javier Naval Departamento de Bioquı́mica, Biologı́a Molecular y Celular, Facultad
de Ciencias, Universidad de Zaragoza, Zaragoza, Spain
Scott A. Ness Department of Molecular Genetics & Microbiology, University of
New Mexico Health Sciences Center, Albuquerque, NM, USA
Ryan H. Newton Institute for Immunology and Department of Molecular Biology &
Biochemistry, University of California, Irvine, CA, USA
Hoa B. Nguyen Department of Biochemistry and Molecular Biology, Indiana
University School of Medicine, Indianapolis, IN, USA
Natalie M. Niemi Van Andel Institute Graduate School, Van Andel Research
Institute, Grand Rapids, MI, USA
Center for Cancer Genomics and Quantitative Biology, Van Andel Research Institute,
Grand Rapids, MI, USA

Contributors

Contributors

xxxi

Volker Nimmrich Neuroscience Research, GPRD, Abbott, Ludwigshafen, Germany
Hiroshi Nishihara Graduate School of Medicine, Laboratory of Translational
Pathology, Hokkaido University, Sapporo, Japan
Karen Nolan UCD Diabetes Research Centre, UCD Conway Institute, School of
Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
Sofia Nolasco Instituto Gulbenkian de Ciência, Oeiras, Portugal
Escola Superior de Tecnologia da Saúde de Lisboa, Lisboa, Portugal
Instituto de Investigação Cientı́fica Tropical CIISA, Lisboa, Portugal
Mio Nonaka Department of Neurochemistry, The University of Tokyo Graduate
School of Medicine, Bunkyo-ku, Tokyo, Japan
Christopher A. O’Callaghan Centre for Cellular and Molecular Physiology,
Nuffield Department of Clinical Medicine, University of Oxford, Headington,
Oxford, UK
Masato Okada Department of Oncogene Research, Research Institute for Microbial
Diseases, Osaka University, Suita, Osaka, Japan
Shinichiro Oku Division of Membrane Physiology, Department of Cell Physiology,
National Institute for Physiological Sciences, Okazaki, Aichi, Japan
Department of Physiological Sciences, School of Life Science, The Graduate
University for Advanced Studies (SOKENDAI), Aichi, Japan
Hiroyuki Okuno Department of Neurochemistry, The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan
Martin Olivier Departments of Medicine and of Microbiology and Immunology,
The Research Institute of The McGill University Health Centre, McGill University,
Montréal, Québec, Canada
Michael F. Olson Molecular Cell Biology Laboratory, Beatson Institute for Cancer
Research, Glasgow, UK
Kenji Omori Advanced Medical Research Laboratories, Mitsubishi Tanabe Pharma
Corporation, Yokohama, Kanagawa, Japan
Dana Onica Department of Biochemistry, Schulich School of Medicine & Dentistry,
The University of Western Ontario, London, ON, Canada
Laura O’Regan Department of Biochemistry, University of Leicester, Leicester, UK
Alberto Ortiz Unidad de Dialisis, IIS-Fundacion Jimenez Diaz, Universidad
Autonoma de Madrid, Madrid, Spain
Siân-Eleri Owens Institute of Life Science, School of Medicine, Swansea University, Swansea, Wales, UK
Thomas L. Pallone Department of Medicine, Division of Nephrology, University of
Maryland, Baltimore, Baltimore, MD, USA
Søren Paludan Sheikh Department of Clinical Biochemistry and Pharmacology,
Odense University Hospital, University of Southern Denmark, Odense, Denmark

xxxii

John Papaconstantinou Department of Biochemistry and Molecular Biology,
University of Texas Medical Branch, Galveston, TX, USA
Department of Human Biological Chemistry and Genetics, The University of Texas
Medical Branch, Galveston, TX, USA
Pooja Parameswaran Department of Pharmacology, University of Minnesota,
Minneapolis, Minneapolis, MN, USA
Morag Park Goodman Cancer Research Centre, McGill University, Montréal,
Canada
Department of Biochemistry, McGill University, Montréal, Quebec, Canada
Department of Medicine, McGill University, Montréal, Canada
Department of Oncology, McGill University, Montréal, Canada
Gibeom Park Department of Biomedical Sciences, Seoul National University
College of Medicine, Jongnogu, Seoul, South Korea
Haein Park Department of Anatomy and Structural Biology, Albert Einstein
College of Medicine, Jack and Pearl Resnick Campus, Bronx, NY, USA
Woong-Yang Park Department of Biomedical Sciences, Seoul National University
College of Medicine, Jongnogu, Seoul, South Korea
Federico Paroni Center for Biomolecular Interactions, University of Bremen,
Bremen, Germany
Surojit Paul Neurology, University of New Mexico Health Sciences Center,
Albuquerque, NM, USA
Sudesh Pawaria Department of Immunology, University of Pittsburgh, Pittsburgh,
PA, USA
Andrew J. Payne Department of Ophthalmology, University of Missouri - Kansas
City School of Medicine, Vision Research Center, Kansas City, MO, USA
Andrew A. Peden Cambridge Institute for Medical Research, University of
Cambridge, Cambridge, UK
Kimberly J. Perry Department of Cell and Developmental Biology, University of
Illinois at Urbana-Champaign, Urbana, IL, USA
João Bosco Pesquero Biophysics Department, Universidade Federal de São Paulo,
São Paulo, Brazil
Yuri K. Peterson Department of Pharmaceutical and Biomedical Sciences, The
Medical University of South Carolina, Charleston, SC, USA
Carlo Petosa Institut de Biologie Structurale Jean-Pierre Ebel, UMR 5075 (CEA/
CNRS/Université Joseph Fourier), Grenoble, France
Pavel P. Philippov Department of Cell Signalling, A.N. Belozersky Institute of
Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow,
Russia

Contributors

Contributors

xxxiii

Paula A. Pino Department of Biology and South Texas Center for Emerging
Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, USA
Joshua T. Piotrowski Department of Immunology, College of Medicine, Mayo
Clinic, Rochester, MN, USA
Randy Y. C. Poon Division of Life Science, Hong Kong University of Science and
Technology, Kowloon, Hong Kong
Jacques Pouysségur Institute of Developmental Biology and Cancer, CNRS
UMR6543, Université de Nice, Nice, France
Jonay Poveda Unidad de Dialisis, IIS-Fundacion Jimenez Diaz, Universidad
Autonoma de Madrid, Madrid, Spain
David R. Poyner School of Life and Health Sciences, Aston University, Birmingham,
UK
Marco A. M. Prado Robarts Research Institute, University of Western Ontario,
London, ON, Canada
John J. Priatel Department of Pathology and Laboratory Medicine, Child
and Family Research Institute, University of British Columbia, Vancouver, BC,
Canada
Claude Prigent CNRS, UMR 6061, Institut Génétique et Développement de
Rennes, Rennes, France
Université Rennes 1, UEB, IFR, 140, Faculté de Médecine, Rennes, France
Shiri Procaccia Department of Biological Regulation, The Weizmann Institute of
Science, Rehovot, Israel
Rainer Prohaska Max F. Perutz Laboratories (MFPL), Medical University of
Vienna, Vienna, Austria
Véronique Proux-Gillardeaux Membrane Traffic in Neuronal & Epithelial Morphogenesis, INSERM ERL U950, Paris, France
Program in Development & Neurobiology, Jacques Monod Institute, CNRS
UMR7592, Paris, France
University Denis Diderot–Paris 7, Paris, France
Membrane Traffic in Neuronal and Epithelial Morphogenesis; Program in Development, Jacques Monod Institute CNRS UMR7592, Equipe INSERM ERL U950,
CNRS & Univ. Denis Diderot/Paris 7, Paris, Cedex 13, France
Lawrence A. Quilliam Department of Biochemistry and Molecular Biology,
Indiana University School of Medicine, Indianapolis, IN, USA
Leonard Rabinow Université Paris Sud, CNRS UMR 8195, Orsay, France
Pia Ragno Department of Chemistry and Biology, University of Salerno, Fisciano,
Salerno, Italy
Joe W. Ramos The Cancer Research Center of Hawaii, University of Hawaii,
Honolulu, HI, USA

xxxiv

Chotirat Rattanasinchai Cell & Molecular Biology Program, Michigan State
University, East Lansing, MI, USA
Jens Rauch Systems Biology Ireland, University College Dublin, Dublin, Ireland
Moran Rawet-Slobodkin Department of Biological Chemistry Ullman Building,
Weizmann Institute of Science, Rehovot, Israel
Prabir Ray Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, and Department of Immunology, University of Pittsburgh School
of Medicine, Pittsburgh, PA, USA
Anuradha Ray Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, and Department of Immunology, University of Pittsburgh School
of Medicine, Pittsburgh, PA, USA
David Reboutier CNRS, UMR 6061, Institut Génétique et Développement de
Rennes, Rennes, France
Université Rennes 1, UEB, IFR, 140, Faculté de Médecine, Rennes, France
Annegret Reinhold Institute for Molecular and Clinical Immunology, Otto von
Guericke University Magdeburg, Magdeburg, Germany
Carlos Eduardo Repeke OSTEOimmunology lab, Department of Biological
Sciences, School of Dentistry of Bauru, São Paulo University – FOB/USP, Bauru,
SP, Brazil
Michael Reschen Centre for Cellular and Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK
Nicolas Reymond Randall Division of Cell and Molecular Biophysics, King’s
College London, London, UK
Anne J. Ridley Randall Division of Cell and Molecular Biophysics, King’s College
London, London, UK
Steven Ringquist Division of Immunogenetics, Department of Pediatrics, Rangos
Research Center, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Anne C. Rintala-Dempsey Department of Biochemistry, The University of Western
Ontario, London, ON, Canada
Bernard Robaye Institute of Interdisciplinary Research, School of Medicine,
Université Libre de Bruxelles, Gosselies
David D. Roberts Laboratory of Pathology, Center for Cancer Research, National
Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Aaron M. Robitaille Growth and Development, Biozentrum, University of Basel,
Basel, Switzerland
Melissa Rodriguez Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USA
Marco A. Romano-Silva INCT de Medicina Molecular; Departamento de Saúde
Mental, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Contributors

Contributors

xxxv

Daniela V. Rosa INCT de Medicina Molecular, Universidade Federal de Minas
Gerais, Belo Horizonte, Minas Gerais, Brazil
Yvonne Rosenstein Instituto de Biotecnologı́a, Universidad Nacional Autónoma de
México, Cuernavaca, Morelos, Mexico
Anne Roumier Université Pierre et Marie Curie, Institut du Fer à Moulin, Paris,
France
Liat Rousso-Noori Department of Molecular Genetics, Arnold R. Meyer Institute of
Biological Sciences, The Weizmann Institute of Science, Rehovot, Israel
Philippe P. Roux Department of Pathology and Cell Biology, Institute for
Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal,
QC, Canada
Jennifer L. Rudolph Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA
Rosamaria Ruggieri Oncology & Cell Biology, The Feinstein Institute for Medical
Research, Manhasset, NY, USA
J€
urgen Ruland Laboratory for Signaling in the Immune System, Helmholtz
Zentrum M€
unchen – German Research Center for Environmental Health,
Neuherberg, Germany
Third Medical Department, Institute for Molecular Immunology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany
Constance E. Runyan Department of Pediatrics, Northwestern University, Chicago,
IL, USA
Guy A. Rutter Section of Cell Biology, Division of Diabetes, Endocrinology and
Metabolism, Faculty of Medicine, Imperial College London, South Kensington,
London, UK
Kaitlyn Ryan Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA
Fahri Saatcioglu Department of Molecular Biosciences, University of Oslo, Oslo,
Norway
Julie D. Saba Center for Cancer Research, Children’s Hospital Oakland Research
Institute, Oakland, CA, USA
Sarah Sabir Department of Biochemistry, University of Leicester, Leicester, UK
Rachna Sadana Department of Natural Sciences, University of Houston-Downtown,
Houston, TX, USA
Anthony John Sadler Centre for Cancer Research, Monash Institute of Medical
Research, Monash University, Clayton, VIC, Australia
Navdeep Sahota Department of Biochemistry, University of Leicester, Leicester,
UK
Zuzana Saidak Laboratoire de Biochimie, Inserm ERI12 – EA4292, Université de
Picardie Jules Verne (UPJV), Amiens Cedex, France

xxxvi

Vicência Sales Biophysics Department, Universidade Federal de São Paulo, São
Paulo, Brazil
Michael W. Salter Program in Neurosciences & Mental Health, The Hospital for
Sick Children, Toronto, ON, Canada
Ulrich Salzer Max F. Perutz Laboratories (MFPL), Medical University of Vienna,
Vienna, Austria
Asanga Samarakoon Department of Microbiology and Immunology, Life Sciences
Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver,
BC, Canada
Michael S. Samuel Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia
Francisco Sánchez-Madrid Servicio de Inmunologı́a, Hospital Universitario La
Princesa Instituto Investigación Sanitaria Princesa, Madrid, Spain
Maria D. Sanchez-Niño IdI-Paz, IIS-Fundacion Jimenez Diaz, Universidad
Autonoma de Madrid, Madrid, Spain
Monserrat Alba Sandoval-Hernandez Instituto de Biotecnologı́a, Universidad
Nacional Autónoma de México, Cuernavaca, Morelos, Mexico
Jeff M. Sands Renal Division, Emory University Woodruff Memorial Research
Building, Atlanta, GA, USA
Eugenio Santos Centro de Investigación del Cáncer, IBMCC (CSIC/USAL),
University of Salamanca, Salamanca, Spain
Leopoldo Santos-Argumedo Departamento de Biomedicina Molecular, Centro de
Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), México, DF,
México
Ana B. Sanz IdI-Paz, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de
Madrid, Madrid, Spain
Marta Sanz-Garcı́a Instituto de Biologı́a Molecular y Celular del Cáncer, Centro
de Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas (CSIC)Universidad de Salamanca, Salamanca, Spain
Takaya Satoh Department of Biological Science, Graduate School of Science,
Osaka Prefecture University, Sakai, Osaka, Japan
Takashi Sasaki Advanced Medical Research Laboratories, Mitsubishi Tanabe
Pharma Corporation, Yokohama, Kanagawa, Japan
Amy E. Saunders Department of Microbiology and Immunology, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada
Wolfgang W. A. Schamel Max Planck Institute of Immunobiology and Faculty of
Biology, Biology III, University of Freiburg, Freiburg, Germany
Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg,
Germany
Centre of Chronic Immunodeficiency (CCI), University Medical Center Freiburg and
University of Freiburg, Freiburg, Germany

Contributors

Contributors

xxxvii

Tobias M. H. Schenk Laboratory of Signal Transduction, Inositol Signaling
Section, National Institute of Environmental Health Sciences (NIEHS/NIH), NC,
USA
William Schiemann Case Comprehensive Cancer Center, Case Western Reserve
University, Cleveland, OH, USA
Gerd Schmitz Institute of Clinical Chemistry and Laboratory Medicine, University
of Regensburg, Regensburg, Germany
H. William Schnaper Department of Pediatrics, Northwestern University, Chicago,
IL, USA
Burkhart L. Schraven Institute for Molecular and Clinical Immunology, Otto von
Guericke University Magdeburg, Magdeburg, Germany
Annette Sch€
urmann Department of Experimental Diabetology, German Institute of
Human Nutrition Potsdam-Rehbr€ucke, Nuthetal, Germany
Giorgio Scita IFOM, Milan, Italy
Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita’ degli Studi di
Milano, Milan, Italy
John D. Scott Department of Pharmacology, Howard Hughes Medical Institute,
University of Washington School of Medicine, Seattle, WA, USA
Matthew N. Seaman Department of Clinical Biochemistry, Cambridge Institute for
Medical Research, Cambridge, UK
Benedict Seddon Division of Immune Cell Biology, MRC National Institute for
Medical Research, Mill Hill, London, UK
Rony Seger Department of Biological Regulation, The Weizmann Institute of
Science, Rehovot, Israel
Ponniah Selvakumar Department of Pathology and Laboratory Medicine, College
of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
Cancer Research Unit, Saskatchewan Cancer Agency, Saskatoon, SK, Canada
Payel Sen Department of Biochemistry and Molecular Biology, Southern Illinois
University School of Medicine, Carbondale, IL, USA
Banibrata Sen Department of Thoracic/Head and Neck Medical Oncology, Unit
432, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Ameet S. Sengar Program in Neurosciences & Mental Health, The Hospital for Sick
Children, Toronto, ON, Canada
Jean Sévigny Department of Microbiology-Infectiology and Immunology, Centre
de Recherche en Rhumatologie et Immunologie, CHUQ Research Centre, Université
Laval, Quebec, QC, Canada
Ana Sevilla Instituto de Biologı́a Molecular y Celular del Cáncer, Centro de
Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas (CSIC)Universidad de Salamanca, Salamanca, Spain

xxxviii

Patrick M. Sexton Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia
Rajendra K. Sharma Department of Pathology and Laboratory Medicine, College
of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
Cancer Research Unit, Saskatchewan Cancer Agency, Saskatoon, SK, Canada
Gary S. Shaw Department of Biochemistry, The University of Western Ontario,
London, ON, Canada
Stephen B. Shears Laboratory of Signal Transduction, Inositol Signaling Section,
National Institute of Environmental Health Sciences (NIEHS/NIH), NC, USA
Jian-Bing Shen Calhoun Cardiovascular Center, University of Connecticut Health
Center, Farmington, CT, USA
Amanda R. Sherwood Department of Molecular and Cellular Biochemistry,
University of Kentucky College of Medicine, Lexington, KY, USA
Enda Shevlin Department of Biology, Institute of Immunology, National University
of Ireland Maynooth, Maynooth, Co. Kildare, Ireland
Hoon Shim Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA
Takashi Shimizu Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
Marina Tiemi Shio Department of Microbiology and Immunology, The Research
Institute of The McGill University Health Centre, McGill University, Montréal,
Québec, Canada
Kazuhiro Shiozaki Graduate School of Biological Sciences, Nara Institute of
Science and Technology, Ikoma, Nara, Japan
Department of Microbiology, University of California, Davis, Davis, CA, USA
Vladimir P. Shirinsky Institute of Experimental Cardiology, Russian Cardiology
Research Center of the Ministry of Health, Moscow, Russia
David P. Siderovski Department of Pharmacology, University of North Carolina at
Chapel Hill, Chapel Hill, NC, USA
Elcia Maria Silveira OSTEOimmunology lab, Department of Biological Sciences, School of Dentistry of Bauru, São Paulo University – FOB/USP, Bauru,
SP, Brazil
Bernhard B. Singer Department of Anatomy, University Hospital Essen, University Duisburg-Essen, Essen, NRW, Germany
Simona Sivori Dipartimento di Medicina Sperimentale (DI.ME.S.) and Centro di
Eccellenza per la Ricerca Biomedica, Università di Genova, Genova, Italy
Lomon So Department of Molecular Biology & Biochemistry, University of
California, Irvine, CA, USA

Contributors

Contributors

xxxix

Helena Soares Centro de Quı́mica e Bioquı́mica, Faculdade de Ciências,
Universidade de Lisboa, Lisboa, Portugal
Instituto Gulbenkian de Ciência, Oeiras, Portugal
Escola Superior de Tecnologia da Saúde de Lisboa, Lisboa, Portugal
Florentina Soto Department of Ophthalmology & Visual Sciences, Washington
University in St. Louis, St. Louis, MO, USA
David R. Soto-Pantoja Laboratory of Pathology, Center for Cancer Research,
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Erica L. Southgate Department of Pharmacology, University of Illinois College of
Medicine, Chicago, IL, USA
Bruno R. Souza Department of Cell & Systems Biology, Centre for the Analysis of
Genome Evolution and Function, University of Toronto, Toronto, ON, Canada
Annina C. Spilker Goodman Cancer Research Centre, McGill University,
Montréal, Canada
Department of Biochemistry, McGill University, Montréal, Quebec, Canada
Laura Spinelli Division of Cell Signalling and Immunology, College of Life
Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee, UK
Nicole A. St. Denis Centre for Systems Biology, Samuel Lunenfeld Research
Institute, Mount Sinai Hospital, Toronto, ON, Canada
A. Keith Stewart Division of Hematology-Oncology, Mayo Clinic, Scottsdale,
AZ, USA
Peter Storz Department of Cancer Biology, Mayo Clinic Comprehensive Cancer
Center, Jacksonville, FL, USA
Jennifer L. Stow Institute for Molecular Bioscience, The University of Queensland,
Brisbane, QLD, Australia
Lisa Stowers Department of Cell Biology, The Scripps Research Institute, La Jolla,
CA, USA
Julia Strebovsky Department of Infectious Diseases, Medical Microbiology and
Hygiene, University of Heidelberg, Heidelberg, Germany
Emanuel E. Strehler Department of Biochemistry and Molecular Biology, Mayo
Clinic College of Medicine, Rochester, MN, USA
Roland K. Strong Division of Basic Sciences, Fred Hutchinson Cancer Research
Center, Seattle, WA, USA
Justin Sturge Division of Cancer, Department of Surgery & Cancer, Imperial
College London, Hammersmith Hospital, London, UK
Hiroko Sugiura Department of Neuropharmacology, Tokyo Metropolitan Institute
for Neuroscience, Fuchu, Tokyo, Japan
Sarah Sullivan Department of Immunology, Duke University Medical Center,
Durham, NC, USA

xl

Roger J. Summers Drug Discovery Biology, Monash Institute of Pharmaceutical
Sciences, Monash University, Parkville, VIC, Australia
Reshma Sundar Department of Medical Biosciences, Department of Pathology,
Umeå University, Umeå, Sweden
Balaji Sundararaman San Diego State Heart Institute, San Diego State University,
San Diego, CA, USA
Eun-Sil Sung Department of Molecular Science and Technology, Ajou University,
Yeongtong-Gu, Suwon, South Korea
Mark A. Sussman SDSU Heart Institute, San Diego State University Biology
Department, San Diego, CA, USA
Kornelia Molnarne Szauter John A. Burns School of Medicine, University of
Hawaii, Honolulu, HI, USA
Tomohiko Taguchi Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
Yoshimi Takai Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine,
Kobe, Japan
Ken Takamatsu Department of Physiology, Toho University School of Medicine,
Ohta-ku, Toyko, Japan
Hiroshi Takayanagi Department of Cell Signaling, Graduate School of Medical
and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo,
Japan
Japan Science and Technology Agency (JST), Explorative Research for Advanced
Technology (ERATO) Program, Takayanagi Osteonetwork Project, Bunkyo-ku,
Tokyo, Japan
Global Center of Excellence (GCOE) Program, International Research Center for
Molecular Science in Tooth and Bone Diseases, Bunkyo-ku, Tokyo, Japan
Ken-Ichi Takemaru Department of Pharmacological Sciences, Stony Brook
University, Stony Brook, NY, USA
Masaharu Takigawa Department of Biochemistry and Molecular Dentistry,
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical
Sciences, Okayama, Okayama, Japan
Gregory G. Tall Department of Pharmacology and Physiology, University of
Rochester Medical Center, Rochester, NY, USA
Fuyuhiko Tamanoi Molecular Biology Institute, Los Angeles, CA, USA
Department of Microbiology, Immunology & Molecular Genetics, University of
California, Los Angeles, CA, USA
Hisashi Tatebe Graduate School of Biological Sciences, Nara Institute of Science
and Technology, Ikoma, Nara, Japan

Contributors

Contributors

xli

Gregory A. Taylor Departments of Medicine; Molecular Genetics and Microbiology; and Immunology, Duke University, Durham VA Medical Center, Geriatric
Research, Education, and Clinical Center, Durham, NC, USA
Colin W. Taylor Department of Pharmacology, University of Cambridge,
Cambridge, UK
Lars Terenius Department of Clinical Neuroscience, Karolinska Institute,
Stockholm, Sweden
Martina Tesikova Department of Molecular Biosciences, University of Oslo, Oslo,
Norway
Marc J. Tetel Neuroscience Program, Wellesley College, Wellesley, MA, USA
Masafumi Tetsuka Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
Kenneth D. Tew Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, USA
Aiysha Thompson Institute of Life Science, School of Medicine, Swansea University, Swansea, Wales, UK
Priyanka Tibarewal Division of Cell Signalling and Immunology, College of Life
Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee, UK
Pamela Y. Ting Department of Biological Chemistry, David Geffen School of
Medicine at UCLA, Los Angeles, CA, USA
Hiroshi Tokuo Boston Biomedical Research Institute, Watertown, MA, USA
Danyelle M. Townsend Dept of Pharmaceutical and Biomedical Sciences, Medical
University of South Carolina, Charleston, SC, USA
Maria Traver Departments of Medicine; Molecular Genetics and Microbiology;
and Immunology, Duke University, Durham VA Medical Center, Geriatric Research,
Education, and Clinical Center, Durham, NC, USA
Ana Paula Favaro Trombone Pathology lab, Instituto Lauro de Souza Lima ILSL, Bauru, SP, Brazil
Kevin Tsai Department of Pathology and Laboratory Medicine, Child
and Family Research Institute, University of British Columbia, Vancouver, BC,
Canada
Christos Tsatsanis Department of Clinical Chemistry, University of Crete Medical
School, Heraklion, Crete, Greece
Grégory Tufo INSERM UMR-S 769, Université Paris-Sud XI, Châtenay-Malabry,
France
Felipe Francisco Tuon Division of Infectious and Parasitic Diseases, Hospital
Universitario Evangelico de Curitiba, Curitiba, PR, Brazil
Jacob P. Turowec Department of Biochemistry, Schulich School of Medicine &
Dentistry, The University of Western Ontario, London, ON, Canada

xlii

Alvaro C. Ucero IIS-Fundacion Jimenez Diaz and Universidad Autonoma de
Madrid, Madrid, Spain
Daisuke Urano Department of Biology, University of North Carolina, Chapel Hill,
NC, USA
Mikko Uusi-Oukari Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Turku, Finland
Richard Vaillancourt Goodman Cancer Research Centre, McGill University,
Montréal, Canada
Department of Biochemistry, McGill University, Montréal, Quebec, Canada
Alberto Valbuena Instituto de Biologı́a Molecular y Celular del Cáncer, Centro de
Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas (CSIC)Universidad de Salamanca, Salamanca, Spain
Rut Valdor Department of Pathology, Albert Einstein College of Medicine, Bronx,
NY, USA
Filip Van Petegem Department of Biochemistry and Molecular Biology, University
of British Columbia, Vancouver, BC, Canada
Frans van Roy Molecular Cell Biology Unit, Department for Molecular Biomedical
Research, VIB and Ghent University, Ghent, Belgium
Andrea Varga Department of Microbiology and Immunobiology, Center for
Molecular Biology, University of Vienna, Max F. Perutz Laboratories, Vienna,
Austria
Naghmeh Varghayee Clinical Pharmacology Unit, Department of Medicine Austin
Health/Northern Health, University of Melbourne, Heidelberg, VIC, Australia
Martha Vaughan Cardiovascular and Pulmonary Branch, National Heart, Lung,
and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Marta Vázquez-Cedeira Instituto de Biologı́a Molecular y Celular del Cáncer,
Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas
(CSIC)-Universidad de Salamanca, Salamanca, Spain
Francisco M. Vega Instituto de Biologı́a Molecular y Celular del Cáncer, Centro de
Investigación del Cáncer, Consejo Superior de Investigaciones Cientı́ficas (CSIC)Universidad de Salamanca, Salamanca, Spain
Andreia Espı́ndola Vieira OSTEOimmunology Lab, Department of Biological
Sciences, School of Dentistry of Bauru, São Paulo University – FOB/USP, Bauru,
SP, Brazil
Dimitra Virla Molecular & Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, Heraklion, Crete, Greece
Sandhya S. Visweswariah Department of Molecular Reproduction, Development
and Genetics, Indian Institute of Science, Bangalore, Karnataka, India
Maurizio Vitadello CNR-Institute of Neuroscience, Padova section, Padova, Italy

Contributors

Contributors

xliii

Niels Volkmann Bioinformatics and Systems Biology Program, Sanford-Burnham
Medical Research Institute, La Jolla, CA, USA
Vladana Vukojević Department of Clinical Neuroscience, Karolinska Institute,
Stockholm, Sweden
Craig M. Walsh Institute for Immunology and Department of Molecular Biology &
Biochemistry, University of California, Irvine, CA, USA
Angela Wandinger-Ness Department of Pathology and Cancer Center,
MSC08-4640, University of New Mexico Health Sciences Center, Albuquerque,
NM, USA
Yongping Wang Department of Pathology, University of Colorado Denver, Aurora,
CO, USA
Stephen G. Ward Department of Pharmacy & Pharmacology, University of Bath,
Claverton Down, Bath, Somerset, UK
Heather H. Ward Department of Pathology and Cancer Center, MSC08-4640,
University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Nimmi R. Weerasinghe Division of Cell Signalling and Immunology,
College of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee,
UK
Li-Na Wei Department of Pharmacology, University of Minnesota Medical School,
Minneapolis, MN, USA
Brian M. Weist Institute for Immunology and Department of Molecular Biology &
Biochemistry, University of California, Irvine, CA, USA
Emma T. van der Westhuizen Institut de Recherche en Immunologie et
Cancérologie, Université de Montréal, Montréal, QC, Canada
Laura M. Westrate Van Andel Graduate School, Grand Rapids, MI, USA
Van Andel Research Institute, Grand Rapids, MI, USA
John H. White Department of Physiology, McGill University McIntyre Medical
Sciences Building, Montréal, Québec, Canada
Carol Wicking Institute for Molecular Bioscience, The University of Queensland,
Brisbane, QLD, Australia
Janet A. Willment Institute for Medical Sciences, Aberdeen, UK
G. Sebastiaan Winkler School of Pharmacy, Centre for Biomolecular Sciences,
University of Nottingham, Nottingham, UK
James Woodgett Samuel Lunenfeld Research Institute, Mount Sinai
Hospital & Department of Medical Biophysics, University of Toronto, Toronto,
ON, Canada
Hsin-Jung Wu Department of Immunobiology, University of Arizona, Tuscon,
AZ, USA

xliv

Zhihui Xie Laboratory of Allergic Diseases, National Institute of Allergy and
infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Bin Xu Division of Basic Sciences, Fred Hutchinson Cancer Research Center,
Seattle, WA, USA
Jian Xu Child Study Center, School of Medicine, Yale University, New Haven,
CT, USA
Nan Yagishita-Kyo Department of Neurochemistry, The University of Tokyo
Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan
Kanato Yamagata Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
Department of Pharmacology, Shukutoku University, Chuo–ku, Chiba, Japan
Sheng-Wei Yang Department of Chemistry, Tunghai University, Taichung, Taiwan
Jay Yang Department of Anesthesiology, University of Wisconsin, Madison, WI, USA
Xiang-Jiao Yang The Rosalind & Morris Goodman Cancer Research Center,
McGill University, Montréal, Québec, Canada
Departments of Biochemistry and Anatomy & Medicine, McGill University Health
Center, Montréal, Québec, Canada
Departments of Medicine, McGill University Health Center, Montréal, Québec,
Canada
Shin Yasuda Department of Neuropharmacology, Tokyo Metropolitan Institute for
Neuroscience, Fuchu, Tokyo, Japan
Richard D. Ye Department of Pharmacology, University of Illinois College of
Medicine, Chicago, IL, USA
Byong Kwon Yoo Emory University School of Medicine, Division of Digestive
Diseases, Department of Medicine, Atlanta, GA, USA
Linya You The Rosalind & Morris Goodman Cancer Research Center, McGill
University, Montréal, Québec, Canada
Departments of Medicine, McGill University Health Center, Montréal, Québec,
Canada
Howard A. Young Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick,
MD, USA
C. Chris Yun Emory University School of Medicine, Division of Digestive Diseases, Department of Medicine, Atlanta, GA, USA
Michisuke Yuzaki Department of Neurophysiology, School of Medicine, Keio
University, Shinjuku-ku, Tokyo, Japan
Detina Zalli Department of Biochemistry, University of Leicester, Leicester, UK
Cédric Zeltz Department of Biomedicine, University of Bergen, Bergen, Norway

Contributors

Contributors

xlv

Evgeni Yu Zernii Department of Cell Signalling, A.N. Belozersky Institute of
Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow,
Russia
Jiang-Ping Zhang The Rosalind & Morris Goodman Cancer Research Center,
McGill University, Québec, Canada
Department of Medicine, McGill University Health Center, Montréal, Québec,
Canada
Weiguo Zhang Department of Immunology, Duke University Medical Center,
Durham, NC, USA
Min Zhang Institute of Evolution & Marine Biodiversity, Ocean University of
China, Qingdao, China
Chunyan Zhao Department of Biosciences and Nutrition, Novum, Karolinska
Institutet, Huddinge, Sweden
Yixing Zhou Laboratory of Signal Transduction, Inositol Signaling Section,
National Institute of Environmental Health Sciences (NIEHS/NIH), NC, USA
Renping Zhou Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers University,
Piscataway, NJ, USA
Yuan Xiao Zhu Division of Hematology-Oncology, Mayo Clinic, Scottsdale, AZ, USA
Georgios Zilidis Division of Cell Signalling and Immunology, College of Life
Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee, UK

0–9

2-, 3pk (MAPKAPK-2, -3)

5-HT-2B

▶ p38 MAPK Family of Signal Transduction Proteins

▶ 5-Hydroxytryptamine Receptor 2B

5-HT
▶ The 5-HT3 Receptor

5-HT2C
▶ 5-Hydroxytryptamine Receptor 2C

5-HT 2B Receptor
▶ 5-Hydroxytryptamine Receptor 2B

5-HT(2B)

5-Hydroxytryptamine
▶ The 5-HT3 Receptor

▶ 5-Hydroxytryptamine Receptor 2B

5-HT1C

5-Hydroxytryptamine (Serotonin)
Receptor 2B
▶ 5-Hydroxytryptamine Receptor 2B

▶ 5-Hydroxytryptamine Receptor 2C

5-HT2B

5-Hydroxytryptamine 2B Receptor

▶ 5-Hydroxytryptamine Receptor 2B

▶ 5-Hydroxytryptamine Receptor 2B

S. Choi (ed.), Encyclopedia of Signalling Molecules, DOI 10.1007/978-1-4419-0461-4,
# Springer Science+Business Media, LLC 2012

0–9

2

5-Hydroxytryptamine Receptor 2B
Stéphane Doly, Silvina Laura Diaz, Arnauld Belmer,
Anne Roumier and Luc Maroteaux
Université Pierre et Marie Curie, Institut du Fer à
Moulin, Paris, France

Synonyms
5-Hydroxytryptamine (serotonin) receptor 2B; 5Hydroxytryptamine 2B receptor; 5-HT 2B receptor;
5-HT(2B); 5-HT-2B; 5-HT2B; Serotonin receptor 2B

Historical Background
Because of its exquisite sensitivity to serotonin, the rat
stomach fundus was used as a bioassay for serotonin
before the development of more quantitative analytical
assays for this biogenic amine (Vane 1957). Although
the potency for the contractile effects of serotonin has
been known for a long time, the receptors mediating
such a response have eluded definitive characterization
for long time. Pharmacological studies attempting to
characterize the contractile serotonergic receptor in
the rat stomach fundus documented the similarity to
the 5-HT2C receptor. In the absence of detectable
5-HT2C receptor mRNA in the rat stomach fundus,
only molecular cloning allowed the identification of a
new receptor in 1992 in rat and mouse, and later (1994)
human species, called 5-HT2B receptor. Subsequent
pharmacological characterization of this receptor
subtype in different species including humans identified species difference in its pharmacology and confirmed the proximity of this pharmacology to that of
5-HT2C receptors.
Pharmacological analysis has shown that the 5-HT2B
receptor displays high-affinity binding to its endogenous
ligand serotonin (Kd 10 nM), a value significantly
different from that for the 5-HT2A receptor. 5-HT2B
receptors are the targets of many 5-HT2 nonselective
compounds, metabolites of therapeutic compounds, and
drugs of abuse. Agonists include nordexfenfluramine
(metabolite of dexfenflamine), methylergonovine
(metabolite of methysergide), and MDA (metabolite
of MDMA). Tryptamine, a-methyl-serotonin, BW
723C86: 1-methyl-2-[5-(2-thienylmethoxy)-1H-indole-

5-Hydroxytryptamine Receptor 2B

3-yl]ethylamine hydrochloride, D-norfenfluramine, Ro
60-0175: 2(S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)-2propanamine fumarate, and LSD all exhibit the highest
potencies for 5-HT2B. BW 723C86 has been reported to
have over a 10-fold higher selectivity for the 5-HT2B
receptor than the 5-HT2C receptor and a 100-fold
higher selectivity than the 5-HT2A receptor. DOI is a
nearly full agonist at 5-HT2B receptors with similar
affinity to 5-HT2A and 5-HT2B receptors. Nonselective
5-HT2 receptor antagonists such as ritanserin,
metergoline, and LY 53857 antagonize 5-HT2B receptor
mediated effects. Also, the adrenergic a2 receptor
antagonists yohimbine and rauwolscine are potent antagonists and have a low affinity for the 5-HT2C and 5-HT2A
receptor sites. The first highly selective antagonists have
been recently reported, LY266097: 1-(2-chloro-3,4dimethoxybenzyl)-6-methyl-1,2,3,4-tetrahydro-9Hpyrido
[3,4-b]indole hydrochloride, has a pKi of 9.7 for the
human cloned 5-HT2B receptor with a 100-fold greater
selectivity for this receptor than the human 5-HT2C and
5-HT2A sites. SB 204741: N-(1-methyl-5-indolyl)-N0 (3-methyl-5-isothiazolyl)urea, has been reported as
a selective 5-HT2B receptor antagonist with lower
potency (Ki around 100 nM). RS 127445: 2-amino-4(4-fluoronaphth-1-yl)-6-isopropylpyrimidine was found
to have sub-nanomolar affinity for the 5-HT2B receptor
(pKi ¼ 9.5) and a 1,000-fold selectivity for this receptor
as compared to numerous other receptor and ion channel
binding sites and appears to be the most selective, high
affinity 5-HT2B receptor antagonist currently available.
The tetrahydro-b-carboline, LY272015: 6-chloro5-methyl-N-(5-quinolinyl)-2,3-dihydro-1H-indole-1carboxamide is also a selective and potent antagonist.
The SB 206553: 5-methyl-N-(3-pyridyl)-1,2,3,5tetrahydrobenzo[1,2-b:4,5-b0 ]dipyrrole-1-carboxamide
and SB 215505: 6-chloro-5-methyl-N-(5-quinolinyl)2,3-dihydro-1H-indole-1-carboxamide behave as mixed
5-HT2C/5-HT2B receptor antagonist.
Like 5-HT2A and 5-HT2C receptors, the 5-HT2B
receptor when expressed in transfected cells can induce
GTPase activation and inositol 1,4,5-trisphosphate
production upon agonist stimulation. GTPase activation is blocked by antibodies against Gaq/11, but not
by pertussis or cholera toxins or by anti-Gai or antiGas antibodies, indicating that this GTPase activation
is mediated by the G-protein Gaq/11, but not by Gas or
Gai. Interestingly, the GTPase activation can also be
blocked by anti-b1-4, or -g2 subunit antibodies. Agonist stimulation of the 5-HT2B receptor causes a rapid

5-Hydroxytryptamine Receptor 2B

3

5-HT2B R

EGF-PDGF R

Gα13
Gβγ
Gαq

P

cGMP NFκB

P
ERK 1/2

PI3K
eNOS

Cytokines

TACE

5-HT

0–9

iNOS

cGMP

PLC

IP3 DAG

P

Src

PLA2

Cyclin E

AA

Cyclin D

5-Hydroxytryptamine Receptor 2B, Fig. 1 Summary of some of the identified transduction pathways that can be used by
5-HT2B receptors adapted from Nebigil et al. (2000b), Manivet et al. (2000) and Nebigil et al. (2003)

and transient activation of the proto-oncogene product
p21ras in response to serotonin, as measured by an
increase in GTP bound-Ras. Furthermore, 5-HT2B
receptor stimulation activates the mitogen-activated
protein kinases (MAPKs) p42mapk/p44mapk (ERK2/
ERK1). In addition to a mitogenic action, a transforming activity of serotonin can be mediated by the
5-HT2B receptor as it leads to the formation of foci and
to the formation of tumors from foci in nude mice.
Moreover, the 5-HT2B receptors-dependent cell cycle
progression occurs through retinoblastoma protein
hyperphosphorylation and the activation of both cyclin
D1/cdk4 and cyclin E/cdk2 kinases. The induction of
cyclin D1 expression, but not that of cyclin E, is under
mitogen-activated MAPK control, indicating an independent regulation of these two cyclins in 5-HT2B
receptor mitogenesis. Moreover, platelet derived
growth factor receptor (PDGFR) kinase activity is
essential for 5-HT2B-triggered MAPK/cyclin D1, but
not cyclin E, signaling pathways. The 5-HT2B receptor
activation also increases activity of the Src family
kinases c-Src, Fyn, and c-Yes. Strikingly, c-Src, but
not Fyn or c-Yes, is the crucial molecule between the
Gq protein-coupled 5-HT2B receptor and the cell cycle
regulators. Inhibition of c-Src activity is sufficient to
abolish the serotonin-induced: (1) PDGFR tyrosine
kinase phosphorylation and MAPK activation, (2)
cyclin D1 and cyclin E expression levels, and (3)
thymidine incorporation. Thus, c-Src activation by
the 5-HT2B receptor controls cyclin E induction and,
in concert with the receptor tyrosine kinase PDGFR,

induces cyclin D1 expression via the MAPK/ERK
pathway (Nebigil et al. 2000b). The 5-HT2B receptor
can also couple to the phospholipase A2 (PLA2)-mediated release of arachidonic acid. In addition, stimulation of the 5-HT2B receptor triggers intracellular cGMP
production through dual activation of constitutive
nitric-oxide synthase (cNOS) and inducible NOS
(iNOS). The group I PDZ motif at the carboxy terminus
of the 5-HT2B receptor is required for recruitment of
the cNOS transduction pathways, and iNOS stimulation is under control of the Ga13 pathways. 5-HT2B
shares the C-terminal E-X-V/I-S-X-V sequence with
5-HT2C receptors and also binds MUPP1-PDZ
domains in vitro (Manivet et al. 2000) (Fig. 1).
Expression of 5-HT2B receptors has been reported
in mouse embryos in migrating neural crest cells, neural tube, heart primordia, and somites by immunohistochemistry and in situ hybridization. By Northern blot
and immunohistochemistry, 5-HT2B receptor expression has been detected in the stomach fundus, intestine,
liver, kidney, pancreas, spleen, and lung, as well as in
the myocardium of several species including rats,
mice, and humans. In brain, 5-HT2B expression has
been reported in the cerebral cortex, cerebellar nuclei
and their projection areas, lateral septum, dorsal hypothalamus, and medial amygdala. Expression of the
serotonin 5-HT2B receptor mRNA was also confirmed
in several brain nuclei including dorsal raphe nuclei by
gene expression profiling in the mammalian brain, and
by in-situ hybridization. Reports using pharmacological or molecular studies indicate that the 5-HT2B

0–9

0–9

4

5-Hydroxytryptamine Receptor 2B
Brain
Amygdala
Cortex
Cerebellum
Hippocampus
Dorsal raphe

a

Embryo
Neural crest
Neural tube
Heart primordia
Osteoblasts

b

Gut
Enteric nervous system
Smooth muscles
Stomach fundus
Intestine

c

Heart–Lung
Cardiomyocytes
Endothelial cells
Fibroblasts

d

5-Hydroxytryptamine Receptor 2B, Fig. 2 Major sites of
expression of 5-H2B receptors are shown. This includes (a)
brain as illustrated by in situ hybridization on rat brain sections,
(b) embryos as illustrated by in situ hybridization and

immunohistochemistry on mouse embryos, and (c)
immmunohistochemistry on mouse gut and (d) cardiopulmonary
systems, adapted from Choi and Maroteaux (1996), Choi et al.
(1997) and Bonaventure et al. (2002)

receptor is also expressed in blood ve